Centene Corporation Adjusts Start Time for First Quarter 2008 Financial Results Conference Call on April 22, 2008

Centene Corporation (NYSE: CNC) announced today that it has adjusted the start time for its first quarter 2008 financial results conference call to 8:00 AM (Eastern Time) on Tuesday, April 22, 2008, following the release of its earnings results as previously announced at 6:00 AM earlier that morning. The revised start time is intended to accommodate investors by avoiding schedule conflicts. Centene anticipates returning to its originally scheduled time of 8:30 AM (Eastern Time) next quarter. Michael F. Neidorff, Chairman and Chief Executive Officer, and Eric R. Slusser, Executive Vice President and Chief Financial Officer, of Centene Corporation will host the call to review the results.

Investors and other interested parties are invited to listen to the conference call by dialing 800-273-1254 in the U.S. and Canada, 706-679-8592 from abroad, or via a live Internet broadcast on the Companys website at www.centene.com, under the Investor Relations section.

A replay will be available for on-demand listening shortly after the completion of the call until 11:59 PM (Eastern Time) on Tuesday, May 6, 2008, at the aforementioned URL, or by dialing 800-642-1687 in the U.S. and Canada, or 706-645-9291 from abroad, and entering access code 41656800.

About Centene Corporation

Centene Corporation is a leading multi-line healthcare enterprise that provides programs and related services to individuals receiving benefits under Medicaid, including the State Childrens Health Insurance Program (SCHIP) and Supplemental Security Income (SSI). The Company operates health plans in Arizona, Georgia, Indiana, New Jersey, Ohio, South Carolina, Texas and Wisconsin. In addition, the Company contracts with other healthcare and commercial organizations to provide specialty services including behavioral health, life and health management, long-term care, managed vision, nurse triage, pharmacy benefits management and treatment compliance. Information regarding Centene is available via the Internet at www.centene.com.

Contacts:

Centene Corporation
Edmund E. Kroll, Jr.
Senior Vice President, Finance and Investor Relations
212-759-0382
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