Brower Piven Encourages Investors Who Have Losses in Excess of $150,000 From Investment in ISIS Pharmaceuticals, Inc. to Inquire About the Lead Plaintiff Position in Securities Fraud Class Action Lawsuit Before the February 26, 2013 Lead Plaintiff Deadline -- ISIS

STEVENSON, Md., Jan. 4, 2013 (GLOBE NEWSWIRE) -- Brower Piven, A Professional Corporation announces that a class action lawsuit has been commenced in the United States District Court for the Southern District of California on behalf of purchasers of ISIS Pharmaceuticals, Inc. ("ISIS" or the "Company") (Nasdaq:ISIS) common stock during the period between March 29, 2012 and October 15, 2012, inclusive (the "Class Period").

If you have suffered a net loss from investment in ISIS Pharmaceuticals, Inc. common stock purchased on or after March 29, 2012, and held through October 15, 2012, you may obtain additional information about this lawsuit and your ability to become a lead plaintiff by contacting Brower Piven at www.browerpiven.com, by email at hoffman@browerpiven.com, by calling 410/415-6616, or at Brower Piven, A Professional Corporation, 1925 Old Valley Road, Stevenson, Maryland 21153. Attorneys at Brower Piven have combined experience litigating securities and class action cases of over 60 years.

No class has yet been certified in the above action. Members of the Class will be represented by the lead plaintiff and counsel chosen by the lead plaintiff. If you wish to choose counsel to represent you and the Class, you must apply to be appointed lead plaintiff no later than February 26, 2013 and be selected by the Court. The lead plaintiff will direct the litigation and participate in important decisions including whether to accept a settlement and how much of a settlement to accept for the Class in the action. The lead plaintiff will be selected from among applicants claiming the largest loss from investment in the Company during the Class Period. You are not required to have sold your shares to seek damages or to serve as a Lead Plaintiff.

The complaint accuses the defendants of violations of the Securities Exchange Act of 1934 by virtue of the defendants' failure to disclose during the Class Period details concerning the safety and efficacy of Kynamro, which was being developed for the treatment of Homozygous Familial Hypercholesterolaemia. According to the Complaint, following the FDA's October 16, 2012 clinical briefing document which questioned the safety and efficacy of Kynamro, and which noted the presence of abnormal growths or neoplasms in patients treated with Kynamro, the value of ISIS shares declined significantly.

If you choose to retain counsel, you may retain Brower Piven without financial obligation or cost to you, or you may retain other counsel of your choice. You need take no action at this time to be a member of the class.

CONTACT: Charles J. Piven
         Brower Piven, A Professional Corporation
         Stevenson, Maryland
         410/415-6616
         hoffman@browerpiven.com
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