The automatic spending cuts, known as "sequestration" - a result of Congress's 2011 negotiations to raise the debt ceiling - would total $109 billion in 2013, CBS News reported.
Here's a closer look at where the cuts would be targeted.
The Fiscal Cliff Automatic Spending Cuts The automatic spending cuts, which have been opposed by Democrats and Republicans alike, would be divided equally between defense and non-defense spending, CNN reported.
Let's start with defense programs, which represent about 20% of the federal budget and 50% of discretionary spending, which is set annually by Congress.
According to the Office of Management and Budget, discretionary defense spending would be cut by 9.4% to 10.0%, or about $55 billion, from a total of $580 billion.
Half of the defense cuts would be to overseas operations, weapons systems and procurement programs, but military personnel pay and benefits would not be reduced.
Non-defense discretionary programs, one of the smallest slices of the federal budget, would be reduced by 40%.
Democrats will seek to preserve these programs, which include international, aid, funding for NASA, national parks and the Environmental Protection Agency's toxic waste and water cleanup programs. States and cities would see education funding and community block grants cut, and spending for job-training programs, Section 8 and public housing, homeless shelters, law enforcement, Head Start and low-income heating assistance would also be cut.
Sequestration would also bring a 7.6% spending reduction for some entitlement programs, but benefits would not be cut. Cutbacks to Medicare providers would include a 2% reduction in payments to nurses, doctors and insurance plans.
Anne Stauffer, project director at the Pew Center on the States, told CNN about 18% of federal grant money that goes to states would be cut. The spending cuts could total $7.5 billion, and one area especially hard hit would be Title 1 spending for low-income students. Special education funding would be affected the most, and 200,000-plus children could be cut from the Head Start program.
So what's not going to be cut?
Most of Medicare, Medicaid, Social Security and the state Children's Health Insurance Program would be spared, as would food stamps, veterans' benefits and Pell Grants for college students.
If the automatic spending cuts do go into effect, experts believe it will harm the economy.
In fiscal 2013 alone, the Congressional Budget Office has estimated federal spending would decline $65 billion. This could take off two-thirds of 2013's projected economic growth and increase the unemployment rate as high as 1.5 percentage points, according to Steve Fuller, director of the Center for Regional Analysis at George Mason University.
Perhaps the prospect of the automatic spending cuts will provide impetus to reach a fiscal cliff agreement by year's end.
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